Two sample MR report
RPS16_Monocyte (Mono) against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.1102588 | 0.1646500 | 0.5397490 |
| Weighted median | 6 | 0.0987635 | 0.0235808 | 0.0000281 |
| Inverse variance weighted | 6 | 0.1019493 | 0.0189538 | 0.0000001 |
| Simple mode | 6 | 0.0921133 | 0.0335958 | 0.0407042 |
| Weighted mode | 6 | 0.0932652 | 0.0312710 | 0.0307119 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.7854342 | 4 | 0.9403901 |
| Inverse variance weighted | 0.7880155 | 5 | 0.9777914 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0023305 | 0.0458706 | 0.9619162 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002535 | 0 | TRUE | 0.1330822 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
